Avian Polyoma Virus (APV) is a highly contagious and potentially fatal infection that primarily affects young birds, especially psittacine species like parrots. This viral disease is known for its rapid onset and diverse clinical manifestations, including lethargy, weight loss, and hemorrhages. APV is primarily transmitted through direct contact with infected birds, contaminated surfaces, or feather dust. The virus can spread silently within aviaries, impacting both pet and captive breeding populations. Infected birds may succumb to acute illness or become persistently infected, serving as carriers without displaying symptoms. Prevention strategies involve strict hygiene, quarantine measures, and vaccination programs, especially for high-risk species. Early detection is challenging due to the lack of specific symptoms, making regular veterinary check-ups and routine testing crucial in managing and controlling APV outbreaks, safeguarding the health of avian populations in captivity.